The document “Strategic Plan of Vall d’Hebron University Hospital” outlines the methodological framework used to establish a comprehensive strategy at this hospital in Barcelona, Spain. It details how resources were coordinated and key stakeholders were involved to design a plan aimed at optimizing medical care, promoting research, and enhancing clinical education. The primary goal of the plan is to improve patient outcomes and streamline services. This strategic planning model provides a valuable example for setting up effective strategic planning in a Comprehensive Cancer Infrastructure (CCI).